منابع مشابه
Aging, drugs, and drug metabolism.
137 Translational I N this series of special themed editions of the Journal of Gerontology Biological Sciences and Medical Sciences, reviews and commentaries have been solicited that focus on the basic biology, animal models, translational research, physiology, epidemiology, and public health aspects of aging. This emphasizes the multidisciplinary and translational nature of modern aging resear...
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Sirtuins are nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylases that link protein acetylation, metabolism, aging, and diseases of aging. Sirtuins were initially found to slow aging in lower organisms and more recently shown to mediate many effects of calorie restriction on metabolism and longevity in mammals. This chapter focuses on two key mammalian sirtuins, SIRT1 (which r...
متن کاملDrugs and lipid metabolism.
I propose to give a review of the effect of drugs on lipid metabolism which will be extensive rather than intensive. Several excellent reviews are available that discuss the drugs which are most effective for lowering plasma lipid levels in the six main types of human hyperlipoproteinaemia (Lees & Wilson, 1971 ; British Medical Journal, I 972 ; Levy, Fredrickson, Shulman, Bilheimer, Breslow, St...
متن کاملMitochondrial metabolism, sirtuins, and aging.
The sirtuins are a family of proteins that act predominantly as nicotinamide adenine dinucleotide (NAD)-dependent deacetylases. In mammals seven sirtuin family members exist, including three members, Sirt3, Sirt4, and Sirt5, that localize exclusively within the mitochondria. Although originally linked to life-span regulation in simple organisms, this family of proteins appears to have various a...
متن کاملDietary Protein, Metabolism, and Aging.
Dietary restriction (DR), a moderate reduction in food intake, improves health during aging and extends life span across multiple species. Specific nutrients, rather than overall calories, mediate the effects of DR, with protein and specific amino acids (AAs) playing a key role. Modulations of single dietary AAs affect traits including growth, reproduction, physiology, health, and longevity in ...
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ژورنال
عنوان ژورنال: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
سال: 2011
ISSN: 1079-5006,1758-535X
DOI: 10.1093/gerona/glr084